Informatics Publishing Limited

H. H. Gangurde , M. A. Chordiya , N. S. Baste , S. Tamizharasi , C. D. Upasani

Abstract

Targeting drug delivery into the lungs has become one of the most important aspects of systemic or local drug delivery. Consequently, in the last few years, techniques and new drug delivery devices intended to deliver drugs into the lungs have been widely developed. Currently, the main drug targeting regimens include direct application of a drug into the lungs, mostly by inhalation therapy using either pressurized metered dose inhalers (pMDI) or dry powder inhalers (DPI). Intratracheal administration is commonly used as a first approach in lung drug delivery in vivo. To convey a sufficient dose of drug to the lungs, suitable drug carriers are required. These can be solid, liquid, or gaseous excipients. Liposomes, nano and microparticles, cyclodextrins, microemulsions, micelles, suspensions, or solutions are all examples of this type of pharmaceutical carrier that have been successfully used to target drugs into lungs. The use of micro reservoir type systems offers clear advantages, such as high loading capacity and possibility of controlling size and permeability, and thus of controlling the release kinetics of the drugs from the carrier systems. These systems make it possible to use relatively small numbers of vector molecules to deliver substantial amounts of a drug to the target. This review discusses the approaches and devices required to be administer drug into the lungs.

Keywords

Targeting Drug Delivery, Drug Delivery Devices, Pressurized Metered Dose Inhalers, Liposomes, Microparticles.

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Sushil D. Patil ¹, Sunil V. Amurutkar ¹, C. D. Upasani ¹

Affiliations
1 Department of Pharmaceutical Chemistry, SNJB’s (Jain Gurukal) Shriman Sureshdada Jain College of Pharmacy, Neminagar, Chandwad-423101, IN

Abstract

A Stability Indicating RP HPLC method was develop and validated for the determination of Empagliflozin using Phenomenex C₁₈ column (25 cm×4.6 mm, 5μm) with mobile phase consisting of Methanol: Water (70:30% v/v). The flow rate was kept constant 1.0 mL/min and eluent was detected at 224 nm. In calibration curve experiments, Linearity was found to be in concentration range 2-14 μg/mL (R²=0.999) with regression equation Y = 96888x - 25879. Empagliflozin was subject to stress condition including alkaline, acidic, oxidation, wet heat, thermal degradation and photolysis. Empagliflozin is more sensitive towards acid degradation. Also there was no interference of excipient and degradation product at retention time of Empagliflozin, indicating specificity of the method.

Keywords

HPLC, Empagliflozin, Method Development and Validation, ICH Guideline.

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